Protocol Comparison
  FDA regimen Updated regimen: Vaginal misoprostol Updated regimen: Buccal misoprostol
Maximum gestational age 49 days from LMP 63 days from LMP 63 days from LMP
Mifepristone dose 600 mg. orally in office 200 mg. orally in office 200 mg. orally in office
Misoprostol dose 400 mcg. orally
(2 tablets)

800 mcg. vaginally
(4 tablets)

800 mcg. buccally
(4 tablets)

Misoprostol timing 48 hours after mifepristone 6-72 hours after mifepristone 24-36 hours after mifepristone
Misoprostol location Clinician’s office Home Home
Follow-up visit 14 days after mifepristone 2-14 days after mifepristone 2-14 days after mifepristone
Minimum number of office visits 3 2 2
Cost Higher Lower Lower

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